Ocular Surface Reconstruction With Cultivated Autologus Mucosal Epithelial Transplantation
- Conditions
- Ocular Surface Disease
- Interventions
- Procedure: Cultivated mucosal epithelial transplantation
- Registration Number
- NCT01942421
- Lead Sponsor
- Mahidol University
- Brief Summary
The purpose of this study is to elucidate the appropriate condition of developing cultivated autologous oral mucosal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated cells in the patients.
- Detailed Description
Ocular surface damage caused by severe ocular surface diseases. Corneal limbal stem cell transplantation has been demonstrated to improve the outcome of ocular surface reconstruction. However, the conventional management of allograft limbal transplantation generally has unsatisfactory outcome because of high risk of rejection and requires long-life immunosuppressive medications. Ocular surface reconstruction with cultivated autologous mucosal epithelial transplantation is served to improve the surgical results of ocular surface reconstruction and decrease the use of immunosuppressive medications
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Bilateral limbal stem cell deficiency proved by specific clinical features and impression cytology
- Age under 18
- Active ocular infection, Severe dry eye, Uncontrolled glaucoma
- Immunocompromised host
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Cultivated mucosal epithelial transplant Cultivated mucosal epithelial transplantation Cultivated mucosal epithelial transplantaion to limbal deficiency patients
- Primary Outcome Measures
Name Time Method Ocular surface clinical and pathological status(signs of limbal deficiency and immunopathological markers)after the surgery Three years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pinnita Prabhasawat, MD
🇹🇭Bangkok, Thailand