Epithelial cell transfer for severe corneal disease

Phase 1

Completed

• Conditions: imbal stem cells deficiency; Limbal stem cells deficiency; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12607000211460
• Lead Sponsor: Inflammatory Diseases Research Unit, School of Medical Sciences, University of NSW

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-04-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

* patients with limbal stem cell deficiency diseases* patients capable of giving written informed consent and complying with the study protocol.

Exclusion Criteria

* patients with corneal perforationpatients with autoimmune disease (e.g rheumatoid arthritis, MOoren's ulcer, lupus etc)*active bacterial, fungal, or amoebic ulcers*vitamin A deficiency* pregnant or lactating women* viral infections.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A stable and healthy corneal epithelium. Indicators of a healthy cornea may include healing of a corneal ulcer or inhibition of conjunctivilisation. [Ocular health will be monitored twice weekly with the contact lense left over the affected eye, then weekly over the next 4-weeks, monthly over the next 6-months, then 6-monthly over the next two years.]

Secondary Outcome Measures

Name	Time	Method
Corneal epithelial integrity and re-surfacing.[ Both parameters will be measured twice weekly for the first two weeks, weekly for the next 4-weeks, monthly for the next 6-months, then 6monthly for the following 2-3 years.]