Study on the brain effect of scalp acupuncture treatment of vascular dementia based on DTI

Phase 1

Recruiting

• Conditions: Vascular dementia

• Registration Number: ITMCTR2000003058
• Lead Sponsor: Shuguang Hospital Affiliated to Shanghai University of TCM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Right-handed, aged40-80 years, regardless of gender;
2. MRI and / or CT support the existence of ischemic cerebrovascular disease, which accords with the diagnostic criteria of NINDS-AIREN;
3. The education level above primary school (including primary school);
4. Meets the diagnostic criteria of dementia (DSM-IV);
5. Meeting the probable VaD diagnostic criteria of NINDS-AIREN;
6. Modified Hachinski Ischemia scale (MHIS), total score >= 4;
7. Patients with mild or moderate severity: 10 <= MMSE <= 26 and 1 <= CDR <= 2;
8. Hamilton depression scale, HAMD total score of Hamilton Depression scale <= 17;
9. There is no taboo on MRI scanning.

Exclusion Criteria

1. There was memory or other cognitive dysfunction in the past, but no obvious ischemic focus on the image;
2. With cognitive impairment caused by trauma, tumor, infection, thyroid dysfunction, alcoholism, etc;
3. With severe vision, hearing impairment and aphasia, affect the examination or can not cooperate with the dementia scale evaluation or can not cooperate with the head immobilization; 4. With anxiety, depression, mental disorder and disturbance of consciousness;
5. With abnormal laboratory indexes;
6. With severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina pectoris, uncontrollable asthma, active gastric hemorrhage, etc.) and cancer;
7. Pregnant or lactating women;
8. With history of brain trauma or cerebral hemorrhage within 1 month;
9 With contraindications for MR examination;
10. Taken a acupuncture treatment in the past 4 weeks;
11. Unable to complete the basic course of treatment, poor compliance (that is, unable to adhere to treatment) and difficult to follow up in the future.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MMSE;fractional?anisotropy;mean diffusivity;VaDAS-cog;