Value of Additional Corpus Biopsy for Diagnosis of H Pylori in Atrophic Gastritis. Prospective Non-randomized Multicenter Study
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Mansoura University
- Enrollment
- 400
- Locations
- 1
- Primary Endpoint
- H PYLORI POSITIVITY
Study Overview
Brief Summary
There are controversies about the best sites -biopsy based -tests for H pylori associated gastritis. The study is designed to evaluate the optimal site of gastric mucosal biopsy for identification of Helicobacter pylori, especially in case of gastric atrophy and/or intestinal metaplasia.
Detailed Description
. The study is designed to evaluate the optimal site of gastric mucosal biopsy for identification of Helicobacter pylori, especially in case of gastric atrophy and/or intestinal metaplasia. 400 patients with dyspepsia are planned to be enrolled in this study. in addition to the routine antral biospy, corpus biospies are taken to evaluate the optimal site of gastric mucosal biopsy for identification of Helicobacter pylori, especially in case of gastric atrophy and/or intestinal metaplasia.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients included in this study are those with peptic ulcer disease, previous upper gastrointestinal surgery, a known or a suspected past history of H.pylori eradication therapy, a personal or first-degree family history of gastric cancer
Exclusion Criteria
- •those having received antibiotic or proton pump inhibitor treatment one month beforehand
Outcomes
Primary Outcomes
H PYLORI POSITIVITY
Time Frame: 2 YEARS
Secondary Outcomes
No secondary outcomes reported
Investigators
MOHAMED ABDELLATIF
ass. prof.
Mansoura University