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Mindfulness Meditation Versus Clinical Hypnosis for Acute, Experimental Pain

Phase 2
Completed
Conditions
Clinical Hypnosis
Mindfulness Meditation
Interventions
Behavioral: Clinical hypnosis
Behavioral: Mindfulness meditation
Registration Number
NCT04786405
Lead Sponsor
The University of Queensland
Brief Summary

This trial aims to determine the effects and mechanisms (mediators and moderators) of brief training in mindfulness meditation versus clinical hypnosis on acute, experimental pain.

Detailed Description

Participants (N=200 with complete data) will be healthy undergraduate students or community-based individuals. An experimental, randomised trial will be implemented, with participants randomly assigned to either five daily, 20-minute mindfulness meditation sessions or clinical hypnosis sessions. Repeated measures and experimental pain manipulation will be implemented. Aim 1 is to examine the effects of these two treatments on experimental pain outcomes. Aim 2 is to examine the moderators of these effects. Aim 3 is to determine the mediators underlying improved experimental pain outcomes. Results will refine theory and will inform the future streamlining of treatments to target those mechanisms shown to be of most critical importance.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
105
Inclusion Criteria
  • 18 years of age or older;
  • Able to read, speak and understand English.
Exclusion Criteria
  • Pregnancy, heart or vascular disease, Raynaud's disease, sickle cell disease, seizure disorder, high blood pressure, or diabetes;
  • Experience of recurrent fainting spells;
  • Report of a chronic pain condition;
  • Use of alcohol and/or pain medication in the last 24-hours;
  • Currently receiving psychiatric care;
  • Problems with allergic skin reactions or excessive bruising;
  • Previous participation in a cold pressor experiment.
  • All participants will be asked to consume a fruit box drink prior to the cold pressor to prevent vasovagal reactions.

These exclusion criteria are standard when using a cold pressor task in a healthy undergraduate population and ensure safe procedures to mitigate any potential risks.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Clinical HypnosisClinical hypnosisParticipants in this arm will complete five, 20-minute clinical hypnosis sessions delivered over consecutive days.
Mindfulness MeditationMindfulness meditationParticipants in this arm will complete five, 20-minute mindfulness meditation sessions delivered over consecutive days.
Primary Outcome Measures
NameTimeMethod
Pain unpleasantnessChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Numerical rating scale in response to exposure to a cold pressor task.

Pain intensityChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Numerical rating scale in response to exposure to a cold pressor task.

Pain toleranceChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

How long (in seconds) participants tolerate the cold pressor task with the time starting at the point of immersion and stopping when the hand, wrist and forearm were withdrawn from the refrigerated water.

Secondary Outcome Measures
NameTimeMethod
Mechanism: Attention Network TaskChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

A computer based task that has been developed to allow assessment of the functioning of the three major attentional networks; alerting, orienting, and executive attention.

Mechanism: MindfulnessChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Five Facet Mindfulness Questionnaire-Short Form

Physiological response to pain stimulusChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Heart rate data

Mechanism: Mind Wandering TaskChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

A computer based task that has been developed to allow assessment of three types of mind wandering.

Mechanism: Pain appraisalsChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Pain Appraisal Inventory

Mechanism: HypnotizabilityBaseline score at Experimental Session 1 (Day 1)

Stanford Clinical Hypnotizability Scale

Mechanism: Pain catastrophizingChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Pain Catastrophizing Scale

Mechanism: Pain-Related Cognitive ProcessesChange from Experimental Session 1 (Day 1) to Experimental Session 5 (Day 5)

Pain-Related Cognitive Process Questionnaire34

Mechanism: Pre-treatment expectanciesBaseline score at Experimental Session 1 (Day 1)

Treatment Expectations Questionnaire

Trial Locations

Locations (1)

The University of Queensland

🇦🇺

Brisbane, Queensland, Australia

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