Effects of Mode of Contraction on Neuromuscular Fatigue
- Conditions
- Volunteers
- Interventions
- Diagnostic Test: 6 Minutes Walk TestBehavioral: Mini Mental State ExaminationDiagnostic Test: Timed up and goDiagnostic Test: Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test)Diagnostic Test: Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test)Diagnostic Test: Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test)
- Registration Number
- NCT04516538
- Brief Summary
Aging is associated with multiple deteriorations of the neuromuscular system. Given the increase in life expectancy, the investigators can now distinguish old adults (\>60 years old) who conserve their neuromuscular capacities with regular physical activity and very old adults (\>80 years old) who suffer from an inexorable decline, even if the number of octogenarians and their quality of life are progressively increasing. However, the most part of the literature on fatigue and neuromuscular capacity with aging focused on isometric tasks. The results showed a significant decrease in maximal force production capacity and a greater resistance to fatigue for old people compared to the young population. When fatigue is induced trough dynamic contractions, greater fatigability was observed in old adults compared to young adults. Investigations performed on the population aged over 80 years old are rare, showing greater fatigability in octogenarians than old men (aged 60-80 years old) during isometric tasks. The knowledge about the effects of dynamic contractions in this population are limited, and performed uniquely in single leg isokinetic mode. Evaluations that require the use of both legs and higher muscle mass involved in the task (cycloergometer) are needed. Understanding neuromuscular fatigue and fatigability across different exercise modalities is necessary to set adapted physical activity programs aimed to maintain autonomy in older individuals.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 65
- Belong to a defined age group: young (18 to 35 years old inclusive), old (60 to 80 years old inclusive) and very old (81 to 95 years old inclusive),
- Signed written consent form
- Being affiliated to social security
- Pathology or surgery resulting in a locomotor disorder, within 6 months prior to the study,
- Chronic neurological, motor or psychological pathologies
- Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) for the duration of the study.
- Contraindication to magnetic stimulation:
- Cardiac or respiratory insufficiency.
- Cardiac pacemaker.
- Cardiac valve wear and serious cardiovascular diseases.
- Presence of prosthetic material or ferromagnetic foreign bodies in the head.
- Presence of cochlear implants or ocular prosthetic material.
- History of neurosurgical interventions.
- Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
- History of comitiality, contralateral knee pathology or pathology of the musculoskeletal system.
- Mini Mental State Examination < 20
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Young people Timed up and go Men or Women under 35 years old Young people Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women under 35 years old Old people 6 Minutes Walk Test Men or Women between 60 and 80 years old Young people 6 Minutes Walk Test Men or Women under 35 years old Young people Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women under 35 years old Old people Timed up and go Men or Women between 60 and 80 years old Old people Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women between 60 and 80 years old Very old people Cycloergometer body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women over 80 years old Very old people Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test) Men or Women over 80 years old Young people Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test) Men or Women under 35 years old Old people Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women between 60 and 80 years old Very old people 6 Minutes Walk Test Men or Women over 80 years old Old people Isometric BW-QIF Test (Body weight-based quadriceps intermittent fatigue test) Men or Women between 60 and 80 years old Very old people Mini Mental State Examination Men or Women over 80 years old Very old people Isokinetic Body weight-based quadriceps intermittent fatigue test (BW-QIF Test) Men or Women over 80 years old Very old people Timed up and go Men or Women over 80 years old
- Primary Outcome Measures
Name Time Method Percentage of Maximum Voluntary Contraction (%) - all participants Immediately after pedalling on an ergocycle The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer.
- Secondary Outcome Measures
Name Time Method Percentage of Maximum Voluntary Contraction (%) - 18-35 years old participants Before and immediately after concentric isokinetic contractions The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer.
Percentage of Maximum Voluntary Contraction (%) - 60-80 years old participants Before and immediately after concentric isokinetic contractions The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer.
Percentage of Maximum Voluntary Contraction (%) - more than 80 years old participants Before and immediately after concentric isokinetic contractions The measurement of the maximum voluntary contraction is carried out at rest with the instruction to contract the extensor muscles of the knee as hard as possible by pushing against a fixed pedal. This force is measured by an isokinetic ergometer.
Trial Locations
- Locations (1)
CHU de Saint-Etienne
🇫🇷Saint-Étienne, France