NCT00721201已完成1 期
A Pilot Study of the Effect of a Glucocorticoid Receptor Antagonist in Patients With Subclinical Cushings
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Blood pressure
研究概览
简要总结
The purpose of this study is to assess the effects of reducing the activity of endogenous glucocorticoid in patients with low-grade cortisol excess
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients will be eligible for inclusion if: they are males and over 18, lack clinical features classically associated with Cushing's syndrome; have evidence of excess circulating cortisol
排除标准
- •Evidence of local or systemic malignancy; overt Cushing's syndrome; severe uncontrolled diabetes mellitus or hypertension; pregnancy; clinically significantly impaired cardiovascular function (e.g. stage IV cardiac failure); severe liver disease (liver enzymes ≥ 3 x the institutional upper limit of normal range); significantly impaired renal function (eGFR <30/min); uncontrolled severe active infection; treatment with approved or experimental steroidogenesis inhibitors, adrenolytic agents, within four weeks of admission; In women, known endometrial cancer, history of endometrial hyperplasia or vaginal bleeding of unknown cause; requirement for inhaled or systemic glucocorticoids for existing disease; impaired mental capacity or markedly abnormal psychiatric evaluation that precludes informed consent.
结局指标
主要结局
Blood pressure
时间窗: 8 weeks
次要结局
- Glucose homeostasis(8 weeks)
研究者
研究点 (1)
Loading locations...
相似试验
进行中（未招募）
1 期
A Pilot Study of the Effect of Glucocorticoid Receptor Antagonism in Patients with Sub-Clinical Cushing's Syndrome - Glucocorticoid Receptor Antagonism in Sub-Clinical CushingsEUCTR2007-007604-15-GBSheffield Teaching Hospitals NHS Foundation Trust
招募中
4 期
Minimizing Glucocorticoid Administration in Patients With Proliferative Lupus NephritisLupus NephritisNCT05207358Institutul Clinic Fundeni30
已完成
不适用
A pilot study on prevention of glucocorticoid induced diabetes mellitus by linagliptiPatients scheduled administration of glucocorticoidJPRN-UMIN000015588Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.17
已完成
4 期
Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe BronchiolitisBronchiolitis, ViralNCT02571517Fundació Sant Joan de Déu94
Unknown
不适用
Monıtorıng Glucocortıcoıd Treatment In Patıents Followed In Rheumatology ClınıcGlucocorticoids ToxicityRheumatoid ArthritisSystemic Lupus ErythematosusVasculitisNCT05292456Hacettepe University200