Nesiritide for Ventilated Congestive Heart Failure

• Conditions: Congestive Heart Failure; Using Nesiritide; Mechanical Ventilation; Cardiac Function; Venous Return

• Registration Number: NCT04455477
• Lead Sponsor: Shanghai Zhongshan Hospital

Brief Summary

The congestive heart failure is a common disease among patients who receive cardiac surgery and may lead to prolonged ventilation support. Nesiritide was a potential therapy for congestive heart failure. This study aimed to compare the Nesiritide induced hemodynamical status changes among congestive heart failure patients with invasive ventilation support.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-14
• Study First Submitted: 2020-05-16
• Status Verified: 2020-06
• Study First Submitted QC: 2020-06-28
• Last Update Submitted: 2020-06-28
• Study First Posted: 2020-07-02
• Last Update Posted: 2020-07-02
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age≥18 years；
• Congestive Heart Failure;
• With mechanical ventilation；
• With hemodynamic monitoring devices;
• The physicians made the decision of using Nesiritide.

Exclusion Criteria

• Unstable hemodynamic status；
• Severe renal dysfunction.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of cardiac output	Before and 30-min after using a standard dose of Nesiritide	Changes of cardiac output measured by hemodynamical monitoring tools
Changes of systemic filling pressure	Before and 30-min after using a standard dose of Nesiritide	Changes of the intercept of regression line of paired VR-RAP points at different PEEP levels.

Secondary Outcome Measures

Name	Time	Method
Changes of cardiac function curve	Before and 30-min after using a standard dose of Nesiritide	Using body position changes (±15°) to simulate the change of preload, and therefore depicte the Starling curve
Changes of venous return curve	Before and 30-min after using a standard dose of Nesiritide	Changes of venous return curve depicted by different PEEP setting

Trial Locations

Locations (1)

Zhongshan Hospital; 🇨🇳 Xuhui, Shanghai, China