NCT02334930已完成不适用
Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors
University Hospital, Bordeaux1 个研究点 分布在 1 个国家目标入组 13 人开始时间: 2015年4月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- YAP cellular expression by immunohistochemistry study on collected tissues
研究概览
简要总结
PEComa is rare tumor affecting particularly patients with Tuberous Sclerosis. Biological similarities were seen between PEComa and infantile hemangioma. Propranolol is highly efficient to treat infantile hemangioma and we believe that this drug can also be useful for the treatment of PEComa.
Purpose : to understand the mechanism of action of propranolol in PEComas and related pediatric vascular lesions and to select possible novel targets of betablockers in vascular tumors related to PEComas by using YAP oncogene activation as a molecular marker
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who will have biopsy or surgery for PEComa or vascular pediatric tumor (RICH, NICH, hemangioma or pyogenic granuloma)
- •A free, informed and written consent will be established
排除标准
- 未提供
结局指标
主要结局
YAP cellular expression by immunohistochemistry study on collected tissues
时间窗: At inclusion (day 0)]
次要结局
- Beta adrenergic receptors expression by immunohistochemistry study on collected tissues(At inclusion (day 0)])
- Study of Hippo/YAP pathway expression by western-blot, and correlation with propranolol efficacy(At inclusion (day 0)])
- Study of MAP/kinases pathway expression by western-blot, and correlation with propranolol efficacy(At inclusion (day 0)])
- Study of PKA/AMPc pathway expression by western-blot, and correlation with propranolol efficacy(At inclusion (day 0)])
研究者
研究点 (1)
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