HO-1 and Muscle Mitochondrial Dysfunction in Sepsis
- Conditions
- SepsisAtrophy
- Registration Number
- NCT02359240
- Lead Sponsor
- Changhai Hospital
- Brief Summary
The current project was designed to examine dynamic changes in muscle wasting during sepsis. Researchers will focus the mitochondrial dysfunction of muscle cells and investigate the role of HO-1 in it. Researchers interested in identifying factors involved in the pathology of muscle wasting during sepsis.
- Detailed Description
Rapid muscle atrophy or muscle wasting occured to septic patients.Sepsis induced muscle wasting has become a severe, frequent, and persistent complication among critically ill patients. Multiple factors including ubiquitin-proteasome system, proinflammatory cytokines and oxidative stress contribute muscle proteolysis.
It is known that heme oxygenase-1 (HO-1) possesses a variety of functions like anti-inflammatory, antioxidative and anti-apoptosis effects. In order to investigate the mechanisms under the condition, researchers are going to examine the role of HO-1 in muscle atrophy during sepsis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- sepsis, severe sepsis, septic shock
- clinical reason for fixation surgery of femoral fractures
- no informed consent
- medical history of myopathy
- unintended weight loss before surgery or ICU admission
- chronic use of corticosteroids
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method HO-1 mRNA and protein expression, mitochondria function of musculus vastus lateralis 3 days after diagnosis
- Secondary Outcome Measures
Name Time Method length of ICU stay 60 days muscle myosin content 3 days after diagnosis length of mechanical ventilation 60 days
Trial Locations
- Locations (1)
Anesthesiology and Intensive Care, Changhai Hospital
🇨🇳Shanghai, Shanghai, China
Anesthesiology and Intensive Care, Changhai Hospital🇨🇳Shanghai, Shanghai, China