Biochemical Pathways to Skeletal Muscle Atrophy in Human Sepsis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrophy
- Sponsor
- Gregory A. Schmidt
- Locations
- 1
- Primary Endpoint
- Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis
- Status
- Withdrawn
- Last Updated
- 9 years ago
Overview
Brief Summary
Severe sepsis will provoke signals leading to muscle atrophy and weakness. Electrical stimulation will reduce the impact of sepsis.
Detailed Description
Hypothesis 1: Severe sepsis will be associated with downregulation of anabolic signaling molecules and genes, upregulation of catabolic signaling molecules and genes, and the development of histologic and electrophysiologic abnormalities within skeletal muscle. Hypothesis 2: Electrical stimulation will improve muscle strength in patients with sepsis. Hypothesis 3: Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes, and improvement of histologic and electrophysiologic parameters within skeletal muscle of patients with sepsis. Hypothesis 4: The ratio of catabolic:anabolic gene expression on Day 3 will be positively correlated with the severity of clinical weakness on Day 7
Investigators
Gregory A. Schmidt
Professor
University of Iowa
Eligibility Criteria
Inclusion Criteria
- •Severe sepsis for \< 72hr
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Electrical stimulation will be associated with upregulation of anabolic signaling molecules and genes, downregulation of catabolic signaling molecules and genes within skeletal muscle of patients with sepsis
Time Frame: 3 days
Secondary Outcomes
- Electrical stimulation will be associated with improvement of histologic and electrophysiologic and strength parameters within skeletal muscle of patients with sepsis(7 days)