Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Change in N-Back Task
Study Overview
Brief Summary
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
Detailed Description
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Male and female outpatients 18-65 years of age
- •A diagnosis of traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorders meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
Exclusion Criteria
- •Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy.
- •Active substance dependence (except for tobacco and cannabis).
- •Pregnant or nursing females.
- •Inability to participate in testing procedures.
- •Additional exclusion criteria for healthy controls:
- •Diagnosis of psychiatric of neurological disorder
- •Ongoing treatment with any psychotropic medications.
Arms & Interventions
Traumatic Brain Injury
This group consists of individuals diagnosed with traumatic brain injury. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Major Depressive Disorder
This group consists of individuals diagnosed with major depressive disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Bipolar Disorder
This group consists of individuals diagnosed with bipolar disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Schizophrenia
This group consists of individuals diagnosed with schizophrenia. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Attention Deficit Hyperactivity Disorder
This group consists of individuals diagnosed with attention deficit hyperactivity disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Borderline Personality Disorder
This group consists of individuals diagnosed with borderline personality disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Substance Use Disorder
This group consists of individuals diagnosed with substance use disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Healthy Controls
This group consists of individuals diagnosed with healthy controls. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
Intervention: Transcranial Direct Current Stimulation (Device)
Outcomes
Primary Outcomes
Change in N-Back Task
Time Frame: Baseline to Post-Treatment, 1 Week
Working Memory Task
Secondary Outcomes
- Change in Multi-Source Interference with International Affective Picture System Task(Baseline to Post-Treatment, 1 Week)
- Change in Stop Signal Task(Baseline to Post-Treatment, 1 Week)
- Change in Iowa Gambling Task(Baseline to Post-Treatment, 1 Week)
- Change in Delayed Discounting Task(Baseline to Post-Treatment, 1 Week)
- Change in Flanker Task(Baseline to Post-Treatment, 1 Week)
Investigators
Joan A Camprodon, MD MPH PhD
Chief of Division of Neuropsychiatry, Director of TMS Clinic, Director of Lab for Neuropsychiatry and Neuromodulation
Massachusetts General Hospital