Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
- Conditions
- Traumatic Brain InjuryAttention Deficit Hyperactivity DisorderBipolar DisorderSchizophreniaBorderline Personality DisorderSubstance Use DisordersMajor Depressive Disorder
- Interventions
- Device: Transcranial Direct Current Stimulation
- Registration Number
- NCT04296604
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
- Detailed Description
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 600
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Traumatic Brain Injury Transcranial Direct Current Stimulation This group consists of individuals diagnosed with traumatic brain injury. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Substance Use Disorder Transcranial Direct Current Stimulation This group consists of individuals diagnosed with substance use disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Healthy Controls Transcranial Direct Current Stimulation This group consists of individuals diagnosed with healthy controls. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Schizophrenia Transcranial Direct Current Stimulation This group consists of individuals diagnosed with schizophrenia. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Major Depressive Disorder Transcranial Direct Current Stimulation This group consists of individuals diagnosed with major depressive disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Bipolar Disorder Transcranial Direct Current Stimulation This group consists of individuals diagnosed with bipolar disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Attention Deficit Hyperactivity Disorder Transcranial Direct Current Stimulation This group consists of individuals diagnosed with attention deficit hyperactivity disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. Borderline Personality Disorder Transcranial Direct Current Stimulation This group consists of individuals diagnosed with borderline personality disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized.
- Primary Outcome Measures
Name Time Method Change in N-Back Task Baseline to Post-Treatment, 1 Week Working Memory Task
- Secondary Outcome Measures
Name Time Method Change in Delayed Discounting Task Baseline to Post-Treatment, 1 Week Decision-Making Task
Change in Stop Signal Task Baseline to Post-Treatment, 1 Week Ability to Inhibit a Response Task
Change in Iowa Gambling Task Baseline to Post-Treatment, 1 Week Risk-Taking Task
Change in Flanker Task Baseline to Post-Treatment, 1 Week Attention and Inhibitory Control Task
Change in Multi-Source Interference with International Affective Picture System Task Baseline to Post-Treatment, 1 Week Cognitive Control During Emotional Regulation Task
Trial Locations
- Locations (1)
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States