Assessing the Cortical Response to Noxious and Auditory Stimuli Using Near Infrared Spectroscopy in Subjects Under General Anesthesia
- Registration Number
- NCT02703090
- Lead Sponsor
- Boston Children's Hospital
- Brief Summary
The primary aim is to utilize near-infrared spectroscopy (NIRS) in patients under general anesthesia to measure changes in brain blood flow in the bilateral somatosensory cortices and the prefrontal cortices in response to noxious stimulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
- 12-30 years of age
- Structurally normal heart
- Right-handed
- English-speaking
Exclusion Criteria
- Unable to cooperate or understand the study
- Neurologic disease
- Diabetes mellitus
- Syndrome of greater than minor severity.
- Smoker
- Scalp or hair does not permit sufficient optical light detection
- Unable to keep his/her head still for a period of 200 consecutive seconds
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Normal saline Normal saline infusion Drug lower dose Remifentanil Remifentanil infusion Drug higher dose Remifentanil Remifentanil infusion
- Primary Outcome Measures
Name Time Method Utilization of NIRS to measure changes in oxyhemoglobin and deoxyhemoglobin in the somatosensory and prefrontal cortices in response to noxious stimulation, and whether these changes are reduced or eliminated by remifentanil. During surgical procedure
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Boston Children's Hospital
🇺🇸Boston, Massachusetts, United States