Reward and Punishment Sensitivity in Bipolar Disorders

• Conditions: Bipolar Disorder
• Interventions: Behavioral: behavioral assessment

• Registration Number: NCT04237610
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical settings. Whereas distinguishing BD-I and BD-II main subtypes has a significant relevance for treatment strategy and for outcome, there are currently no clinical determinants of the BD subtype which could be used as early diagnostic predictors.

* While neurobiological specificity of each BD subtype is still controversial, available evidence suggest different dopaminergic abnormalities in each subtype. Dopaminergic function is involved in decision making and reward processing which may represent useful BD subtype markers.

* This study aims at assessing decision making during appetitive and punitive reinforcement learning in patients with BD I and BD II subtypes compared to healthy controls

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-01-10
• Study First Submitted QC: 2020-01-17
• Study First Posted: 2020-01-23
• Study Start: 2020-02-24
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-03
• Last Update Posted: 2020-09-04
• Primary Completion: 2022-02-23
• Study Completion: 2022-02-23

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• bipolar disorder (BD) type I or II, according to DSM (Diagnostic and Statistical Manual)-5 criteria
• Montgomery and Asberg Depression Rating Scale (MADRS) score < 15
• Young Mania Rating Scale (YMRS) score < 12

Exclusion Criteria

• other main diagnosis than bipolar disorder
• other medical condition leading to cognitive deterioration

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy controls	behavioral assessment	-
Bipolar disorder type I	behavioral assessment	-
Bipolar disorder type II	behavioral assessment	-

Primary Outcome Measures

Name	Time	Method
Response performance in reward and loss trials	one day visit	percentage of correct responses in the probabilistic learning task

Trial Locations

Locations (1)

Chu Grenoble Alpes; 🇫🇷 Grenoble Cedex 9, France