Clinical and Live Birth Rates After Controlled Ovarian Stimulation With the Long Antagonist Protocol Versus the Long Agonist Protocol
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy, Ovarian
- Sponsor
- Assisting Nature
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Clinical Pregnancy Rate according to stimulation protocol
- Last Updated
- 5 years ago
Overview
Brief Summary
A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol
Detailed Description
A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.
Investigators
Papanikolaou Evaggelos
Papanikolaou Evaggelos, MD, PhD, Fertility Specialist, Scientific Director at Assisting Nature IVF Clinic
Assisting Nature
Eligibility Criteria
Inclusion Criteria
- •primary infertility
- •age 18-39 years; body mass index (BMI) 18-29kg/m2;
- •regular menstrual cycle of 26-35days,
- •presumed to be ovulatory;
- •early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l).
Exclusion Criteria
- •women with diabetes and other metabolic disease
- •women with heart disease, QT prolongation,heart failure
- •elevated liver enzymes, liver failure, hepatitis
- •women with inflammatory or autoimmune disease
- •abnormal karyotype;
- •polycystic ovarian syndrome,
- •endometriosis stage III/IV;
- •history of being a 'poor responder',
- •defined as \>20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.
Outcomes
Primary Outcomes
Clinical Pregnancy Rate according to stimulation protocol
Time Frame: 6 weeks to 42 weeks after embryo transfer
Clinical Pregnancy Rate according to stimulation protocol
Number of formed blastocysts in each group of patients
Time Frame: 5 days after the OPU day
The number of the formed blastocysts in each group of patients according to the COS protocol
Secondary Outcomes
- Live Birth Rate according to stimulation protocol(6 weeks to 42 weeks after embryo transfer)