Clinical and Live Birth Rates After Controlled Ovarian Stimulation With the Long Antagonist Protocol Versus the Long Agonist Protocol
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Clinical Pregnancy Rate according to stimulation protocol
研究概览
简要总结
A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol
详细描述
A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •primary infertility
- •age 18-39 years; body mass index (BMI) 18-29kg/m2;
- •regular menstrual cycle of 26-35days,
- •presumed to be ovulatory;
- •early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l).
排除标准
- •women with diabetes and other metabolic disease
- •women with heart disease, QT prolongation,heart failure
- •elevated liver enzymes, liver failure, hepatitis
- •women with inflammatory or autoimmune disease
- •abnormal karyotype;
- •polycystic ovarian syndrome,
- •endometriosis stage III/IV;
- •history of being a 'poor responder',
- •defined as >20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.
结局指标
主要结局
Clinical Pregnancy Rate according to stimulation protocol
时间窗: 6 weeks to 42 weeks after embryo transfer
Clinical Pregnancy Rate according to stimulation protocol
Number of formed blastocysts in each group of patients
时间窗: 5 days after the OPU day
The number of the formed blastocysts in each group of patients according to the COS protocol
次要结局
- Live Birth Rate according to stimulation protocol(6 weeks to 42 weeks after embryo transfer)
研究者
Papanikolaou Evaggelos
Papanikolaou Evaggelos, MD, PhD, Fertility Specialist, Scientific Director at Assisting Nature IVF Clinic
Assisting Nature