Advanced MRI and EEG to Predict Recovery of Consciousness After Severe Traumatic Brain Injury
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Consciousness Disorder
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 79
- Locations
- 1
- Primary Endpoint
- Disability Rating Scale total score
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI) and electroencephalographic (EEG) technologies for predicting functional outcomes in patients with severe traumatic brain injury (TBI).
Investigators
Brian L. Edlow, M.D.
Neurocritical Care Faculty, Massachusetts General Hospital, Associate Director, Center for Neurotechnology and Neurorecovery (CNTR) Director, Laboratory for NeuroImaging of Coma and Consciousness (NICC)
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Traumatic Brain Injury
- •Glasgow Coma Scale score of 3-8 within 24 hours, unconfounded by sedation, paralysis, hypoxia, hypotension, hypothermia, or concurrent medical illness
- •Clinical evidence of disorder of consciousness defined as coma, VS, or MCS
Exclusion Criteria
- •History of prior severe brain injury or dementia
- •Emergence from MCS at time of initial CRS-R assessment
- •Healthy Subjects:
- •Exclusion Criteria:
- •History of brain injury or neurological disease, psychiatric disease, or any history of diabetes, high blood pressure, heart disease, or kidney disease
Outcomes
Primary Outcomes
Disability Rating Scale total score
Time Frame: 6 months post injury
The Disability Rating Scale (DRS) provides quantitative information regarding functional disability in patients recovering from severe brain injury. The total score on the DRS ranges from 0 to 29 with higher scores indicating a greater degree of disability. DRS subscale scores include eye opening \[score range 0-3\], communication \[score range 0-4\], motor response \[score range 0-5\], cognitive ability for feeding \[score range 0-3\], cognitive ability for toileting \[score range 0-3\], cognitive ability for grooming \[score range 0-3\], level of function \[score range 0-5\], and employability \[score range 0-3\]. Subscale scores are summed to produce the total score.