A clinical trial to study effect of changing Albendazole dose and frequency of administration on W.bancrofti(a filarial worm)microfilaria clearance
- Conditions
- Health Condition 1: null- Wuchereia bancrofti infected person
- Registration Number
- CTRI/2013/10/004113
- Lead Sponsor
- Regional Medical Research Centre Chandrasekharpur Bhubaneswar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Treatment
- Age 18 years to 55 years
- Men and non-pregnant or non-breastfeeding women
- Microfilarial levels >50 mf /ml
- Willingness to spend 3 days in hospital
- Willingness to undergo night time blood draws every 6 months for 2 years
- Ability to understand and sign the informed consent
- Hb levels for inclusion >9 g/dl
- Normal Cr, ALT
Treatment
â??Non-volunteers
â??Age < 18 years or > 55 years
â??Pregnancy or breast-feeding
â??Hgb <= 9 g/dL
â??Cr > 1.2/100 ml
â??ALT > 30 U
â??Alcohol consumption of more than 2 beers or other alcohol-containing drink/day within a week of each drug administration
â??Serious medical illness
â??History of benzimidazole allergy
â??History of DEC allergy
â??Use of Albendazole or DEC within past 6 months
â??Unwillingness to comply with required study visits
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method