Beat the pain in Sickle Cell Disease

• Conditions: sickle cell disease; 10018902

• Registration Number: NL-OMON55175
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

• Medical diagnosis of sickle cell disease
• Age from 16 years old
• Written informed consent.

Exclusion Criteria

- Refused informed consent
- For heart rate based measurements: medical history of arrhythmias and chronic
use of medication affecting the heart rate

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters:<br /><br>- Heart related variables: resting heart rate, heartrate/steps-ratio<br /><br>- Variables of Heart Rate variability (e.g. Standard deviation of the R-R<br /><br>intervals = SDNN, RMDD, HF, LF/HF-ratio)<br /><br><br /><br><br /><br>Primary oucomes:<br /><br>A: Occurrence of Acute Chest Syndrome<br /><br>B: Self-reported painful crises</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• Length of stay (LOS)<br /><br>• Need of (P)ICU admission<br /><br>• Need of red blood cell transfusion<br /><br>• Need of analgesic or opioids: maximum dose during hospital admission</p><br>