The Effect of Monitoring Portal Venous Pressure on Clinical Outcomes in Patients With Portal Hypertension: a Prospective, Single-center, Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Ascites
研究概览
简要总结
The complications associated with portal hypertension in cirrhosis are the main cause of death in patients with cirrhosis. The level of portal venous pressure is closely related to the prognosis of patients. HVPG (hepatic venous pressure gradient) is the "gold standard" for predicting portal venous pressure and an important indicator for evaluating the efficacy of NSBBS. However, monitoring HVPG has many limitations，and the clinical application is also limited to a certain extent. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. At the same time, to explore the correlation between HVPG and PPG in cirrhosis patients at different stages and different etiologies, and to evaluate the role of spleen stiffness in predicting the severity of esophageal and gastric varices in patients with portal hypertension, and to find biomarkers to predict the risk of complications related to portal hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •With chronic liver disease
- •Age 18-80 years
- •Patients who require a portal pressure measurement at the discretion of the treating physician
- •Voluntarily signed informed consent
排除标准
- •With serious cardiopulmonary disease or other diseases affect survival
- •With severe renal dysfunction
- •Concomitant portal vein cavernous degeneration or extensive portal vein thrombosis
- •Women who are planning to become pregnant or who are pregnant or breastfeeding
- •The researcher judged that it was not suitable to participate in this study
结局指标
主要结局
Ascites
时间窗: three years
Peritoneal effusion was seen under ultrasound
Hepatic encephalopathy
时间窗: three years
Patients with altered consciousness or unresponsiveness, accompanied by elevated blood ammonia
Gastroesophageal varices bleeding
时间窗: three years
Patients with gastroesophageal varices has hematemesis or melena, and active bleeding or red sign can be seen under endoscopy
次要结局
- Death or final follow-up time (3 years)(three years)