Fetal cardiovascular response to maternal corticosteroid administration: a comparison of dexamethasone versus betamethasone
Not Applicable
Completed
- Conditions
- Fetal cardiovascular status, and its correlation with neonatal outcome and long-term childhood neurosensory disability, following antenatal corticosteroids given to women at risk of preterm birth at less than 34 weeks gestationReproductive Health and Childbirth - Fetal medicine and complications of pregnancy
- Registration Number
- ACTRN12612000282886
- Lead Sponsor
- Dr Amanda Henry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
Women are eligible for the trial if they are at risk of preterm birth at less than 34 weeks gestation, are aged 18-50, have a singleton or twin pregnancy, have no contraindications to the use of antenatal corticosteroids and give informed consent to both the A*STEROID trial and this trial.
Exclusion Criteria
Women are not eligible if they have chorioamnionitis requiring urgent delivery, a higher order multiple pregnancy, have already received antenatal corticosteroids, have known fetal lung maturation, are in the second stage of labour, have an abnormal morphology scan, are taking digoxin or pure beta-blocker, have psychiatric illness precluding informed consent, or have insufficient English for valid consent.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fetal middle cerebral artery pulsatility index measurement as measured by Doppler ultrasound.[Baseline (prior to corticosteroid administration), 24 hours (range 18-30 hours), 48 hours (range 42-54 hours), 96 hours (range 3-5 days), 7 days (range 7-10 days, prior to any repeat dose corticosteroid).];Fetal heart rate short term-variability on cardiotocograph.[Baseline (prior to corticosteroid administration), 24 hours (range 18-30 hours), 48 hours (range 42-54 hours), 96 hours (range 3-5 days), 7 days (range 7-10 days, prior to any repeat dose corticosteroid).]
- Secondary Outcome Measures
Name Time Method