Combined Effect of Repetitive Transcranial Magnetic Stimulation and Task-Specific Trunk Control Training on Postural Stability in Individuals with Parkinson’s Disease.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)- Motor Part -III
Study Overview
Brief Summary
This study was a Randomized Controlled Trial (RCT) investigating the combined effect of Repetitive Transcranial Magnetic Stimulation (rTMS) and Task-specific Trunk Control Training on postural stability in individuals with Parkinson’s Disease (PD). A total of 16 participants met the inclusion criteria and completed the study.
The study was conducted at multiple physiotherapy and neurorehabilitation centers in Patiala, India. Ethical approval was obtained, and informed consent was secured from all participants.
Participants were randomly divided into two groups:
Group A: Received rTMS, Task-specific Trunk Control Training, and Conventional Physiotherapy.
Group B: Received Sham rTMS, Task-specific Trunk Control Training, and Conventional Physiotherapy.
Assessments were conducted at baseline, Day 7, and Day 15 using:
MDS-UPDRS-III (Movement Disorder Society-Unified Parkinson’s Disease Rating Scale - motor part
m-CTSIB (Modified Clinical Test of Sensory Interaction in Balance)
PDQL (Parkinson’s Disease Quality of Life Scale)
The intervention lasted 3 weeks (5 days per week), with progressive exercises focusing on balance, trunk control, and functional mobility. Post-intervention data were analyzed to evaluate improvements in motor function, balance, and quality of life.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 40.00 Year(s) to 75.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Individuals who will be willing to participate and able to give informed consent.
- •Individuals diagnosed with Parkinson’s disease according to ICF domains.
- •Individuals with Hoehn & Yahr stage between 2 and
- •Individuals with a MMSE score more than
- •Individuals with balance deficits (mPOMA score less than 23).
Exclusion Criteria
- •Individuals with any pre-existing neurological disease other than PD.
- •Individuals with any magnetic-sensitive metallic implants close to the stimulation site.
- •Any systematic illness.
- •Presence of any orthopedic disease, visual problems, or vestibular disorders that could affect balance.
- •Surgery in lower limb and spine.
- •Non-cooperative individuals.
Outcomes
Primary Outcomes
Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS)- Motor Part -III
Time Frame: At baseline, day 7, day 15
Secondary Outcomes
- Quality of life-PDQL (Parkinson’s disease quality of life)(At Baseline, day 7, day 15)
- Modified Clinical Test of Sensory Interaction in Balance (m-CTSIB)(At baseline, Day 7, Day 15)