EQUIP - Evaluation of Quality of Imaging on a Next-generation Total Body Pet Scan in Comparison to Conventional PET
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- To assess the diagnostic quality of images acquired on the OMNI 128 Total Body PET
研究概览
简要总结
The GE Healthcare Omni Total Body (TB) 128cms (Omni TB) is a long-axial field-of-view (LAFOV) PET/CT scanner and will be installed in a pre-market phase at the Peter MacCallum Cancer Centre.
The main features and functionality of this new scanner include high sensitivity, high resolution digital detectors based on silicon photomultipliers. The ultra-high sensitivity and extended field of view are designed to support the ability to reduce administrated dose and/or shorten acquisition time without compromising the image quality of the PET imaging.
To verify the appearance of images acquired on the Omni TB with images acquired on our conventional PET/CT equipment, a study imaging a cohort of patients on both devices is proposed. The study involves no additional radiopharmaceutical administration.
Additionally, in keeping with ALARA (as low as reasonably achievable) radiation dose practices, it will be possible to model acquisition settings (duration, administered activity and reconstruction parameters) using the system raw data and a suite of research tools to optimise acquisition parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult, who is at least 18 years of age
- •Referred for a clinically indicated PET/CT scan with radiotracers F-18 FDG, F-18 DCFPyL, Ga-68 PSMA, Ga-68 DOTATATE or I-124
- •Able and willing to provide informed consent for participation in this study
排除标准
- •1) Known to be pregnant or breastfeeding
研究组 & 干预措施
Imaging on Total Body PET
Participants in this arm undergo a total body PET scan after conventional standard-of-care imaging
干预措施: PET (Device)
结局指标
主要结局
To assess the diagnostic quality of images acquired on the OMNI 128 Total Body PET
时间窗: 1 Day
To analyse the diagnostic image quality visually on the Omni TB with radiotracers F-18 FDG, F-18 DCFPyL, Ga-68 PSMA, Ga-68 DOTATATE or I-124
次要结局
- To compare diagnostic image quality on the Omni TB with an existing PET/CT device(1 Day)
- To compare the sharpness and conspicuity of images produced on the Omni TB with an existing PET/CT device(1 Day)
- To compare the noise characteristics of images acquired using the Omni TB with an existing PET/CT device(1 Day)
- To compare the quantitative parameters of SUVmean and SUVmax in normal organs on the Omni TB with an existing PET/CT device(1 Day)
- To quantitatively compare the noise characteristics (signal to noise) of images acquired using the Omni TB with an existing PET/CT device(1 Day)
- To compare the quantitative parameters of SUVmean, SUVmax and SUVpeak in up to three candidate lesions visualised on the Omni TB and an existing PET/CT device(1 Day)
- To evaluate the quality of images obtained by the Omni TB with reduced injected radioactivity(1 Day)
- To compare the visibility of lesions in images acquired using the Omni TB with images acquired on an existing PET/CT device(1 Day)
- To evaluate the quality of images obtained by the Omni TB with reduced scan time(1 Day)