Correlation Of Pre-operative Gallbladder Wall Thickness And C-Reactive Protein With Operative And Post Operative Outcomes Of Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- 1)To asses the pre-operative evaluate gall bladder thickness and C-reactive protein.
研究概览
简要总结
This study aims to establish the predictive value of preoperative gallbladder wall thickness (GBWT) and C-reactive protein (CRP) levels in anticipating intraoperative difficulty, operative time, conversion rates, and postoperative complications in patients undergoing laparoscopic cholecystectomy. The expected outcome is a significant correlation between elevated GBWT/CRP and increased surgical complexity. Identifying these markers preoperatively can aid surgeons in better case selection, improve surgical preparedness, and reduce intraoperative complications. It can also assist in counseling patients regarding possible risks and outcomes, thereby enhancing shared decision-making. This evidence can contribute to clinical guidelines by incorporating GBWT and CRP into preoperative assessment protocols, especially in resource-limited settings where advanced imaging or scoring systems are unavailable. Moreover, it will add to the existing literature on surgical risk stratification and may influence future research on preoperative optimization in biliary surgery. Ultimately, this study has the potential to improve surgical outcomes and promote safer laparoscopic practices.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Undergoing laparoscopic cholecystectomy Preoperative ultrasonographic measurement of gallbladder wall thickness (GBWT)and serum C-reactive protein (CRP) level assessment Provision of informed written consent.
排除标准
- •Gallbladder perforation diagnosed preoperatively Choledocholithiasis Pregnancy Recent trauma Active malignancy Concurrent other infections or sepsis Patient on Anti-inflammatory drugs Uncontrolled systemic comorbidities Patients unwilling or withdrawing consent.
结局指标
主要结局
1)To asses the pre-operative evaluate gall bladder thickness and C-reactive protein.
时间窗: Pre-op US GB wall thickness: within 7 days prior to surgery (document exact interval). | Baseline CRP: within 48–72 hours prior to surgery . | Follow-ups: after 7–10 days and 30 ±7 days (for post operative outcomes).
2) To evaluate the association of preoperative gallbladder wall thickness (GBWT)) with operative difficulty (using Nassar criteria), operative and postoperative outcomes in patients undergoing laparoscopic cholecystectomy. 3) To evaluate the association of C-reactive protein (CRP) levels with operative difficulty (using Nassar criteria), operative and postoperative outcomes in patients undergoing laparoscopic cholecystectomy.
时间窗: Pre-op US GB wall thickness: within 7 days prior to surgery (document exact interval). | Baseline CRP: within 48–72 hours prior to surgery . | Follow-ups: after 7–10 days and 30 ±7 days (for post operative outcomes).
次要结局
- 1) To determine the predictive value of combined GBWT and CRP in anticipating intraoperative complexity.(2) To analyze the correlation of GBWT and CRP levels with postoperative complications like wound infection, bile leak, jaundice.)
研究者
Dr Patel Akash Nareshkumar
Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research