Mapping of Ventricular Fibrillation (VF) Substrates and VF Arrhythmogenic Sources/Reentrant Circuits in Patients With Brugada and Early Repolarization Syndromes

Pacific Rim Electrophysiology Research Institute2 sites in 1 country50 target enrollmentFebruary 23, 2018

ConditionsBrugada Syndrome Early Repolarization Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Brugada Syndrome
Sponsor: Pacific Rim Electrophysiology Research Institute
Enrollment: 50
Locations: 2
Primary Endpoint: VF death
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.

Detailed Description

The investigators will study symptomatic BrS and ERs syndrome (N=25) and asymptomatic patients (N=25) age between 16-70 years old to determine values and limitations of non-invasive mapping using electrocardiographic imaging (ECGI) in identifying VF substrates as target sites for catheter ablations in patients with Brugada (BrS) and Early repolarization syndromes (ERS) and also determine the mechanisms of VF in BrS and ERs syndromes.

Registry

clinicaltrials.gov

Start Date

February 23, 2018

End Date

September 1, 2024

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Pacific Rim Electrophysiology Research Institute

Responsible Party

Principal Investigator

Koonlawee Nademanee, MD

Principal Investigator

Pacific Rim Electrophysiology Research Institute

Eligibility Criteria

Inclusion Criteria

•Patients presenting with the type1 BrS ECG or ER ECG signature pattern, with/without a sodium channel blocker. Patients with the following one of these symptoms or arrhythmias will be considered as symptomatic patients: 1) aborted cardiac arrest cases, 2) documented VF episodes, 3) agonal respiration during sleep with difficulty to arouse, 4) syncope of unknown origin, or 5) seizure suspected of arrhythmic origin.•

Exclusion Criteria

•Patients who refuse informed consent and to participate to the best ability in the study.
•Patients who have structural heart disease or concomitant medical illness.