KCT0003963
Not yet recruiting
未知
Prospective cohort study for genomic evaluation in patients with diffuse large B cell lymphoma after first relapse/progression
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Samsung Medical Center
- Enrollment
- 200
- Status
- Not yet recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Patients with histopathologically confirmed DLBCL
- •2\.Patients diagnosed with DLBCL who relapsed or were refractory to first\-line treatment with rituximab\-based immunotherapy
- •3\.Patients available for genomic analysis of tissues both at diagnosis (paraffin\-embedded and stored) and at relapse (paraffin\-embedded)
- •4\.Patients aged \=18 years
- •5\.Patients who provide written informed consent for participation in the prospective cohort study
- •6\.Patients who provide written informed consent to peripheral blood collection and genetic testing of human tissues
Exclusion Criteria
- •1\.Patients who have no lymphoid malignancy, e.g. myeloid leukemia
- •2\.Patients with any of the following lymphoid malignancies:
- •1\)Plasma cell dyscrasia, amyloidosis
- •2\)Hodgkin lymphoma
- •3\)Subtypes of B cell non\-Hodgkin lymphoma, other than DLBCL
- •4\)T or NK cell non\-Hodgkin lymphoma
- •5\)Other diseases in the WHO classification of lymphoid malignancies
- •3\.Patients who have experienced a relapse before
- •4\.Patients with insufficient or no tissue sample at diagnosis for genomic analysis
- •5\.Patients who do not understand or provide written informed consent
Outcomes
Primary Outcomes
Not specified
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