Standard vs double dose of N-acetylcysteine to prevent contrast indused nephropathy in admitted patients in the angiography department with Glomerular Filtration Rate?60 ml/min, in Kowsar hospital of Semna
Not Applicable
- Conditions
- nephropathy.Diabetic nephropathy
- Registration Number
- IRCT2017052925732N16
- Lead Sponsor
- Semnan University of Medical Sciences, Vice Chancellor for Research and Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 154
Inclusion Criteria
aged 18 and older; glomerular filtration rate less than 60 ml.
Exclusion criteria: pregnant women; lactating mother; dialysis patients; blood pressure; baseline serum creatinine level greater than 7 mg/dL; severe valvular heart disease; autoimmune disorders; acute or chronic diseases; get contrast media in 10 days ago; sensitivity to contrast media or N-acetylcysteine; oliguria (the urine volume less than 400 cc in 24 hours); acute heart failure with preserved ejection fraction <35%; receive supplements of vitamin C in the past week.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum creatinine levels. Timepoint: Before the intervention, 24, 48 and 72 hours after the intervention. Method of measurement: Laboratory.;BUN levels. Timepoint: Before the intervention, 24, 48 and 72 hours after the intervention. Method of measurement: Laboratory.
- Secondary Outcome Measures
Name Time Method