Reducing knee load by changing the walking pattern in patients with knee osteoarthritis

Completed

• Conditions: Knee osteoarthritis; Musculoskeletal Diseases

• Registration Number: ISRCTN14687588
• Lead Sponsor: VU Medisch Centrum

Brief Summary

2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29933935

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-05-30
• Study Start: 2017-08-14
• Last Update Posted: 10 September 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Knee osteoarthritis on the medial compartment based on the ACR criteria
2. Age between 50 and 75 years
3. BMI between 20 and 30kg/m^2
4. Maximum score of 7 on the numeric rating scale (NRS) for pain intensity during the past two weeks
5. Ability to walk independently and unaided (without use of a walking frame, crutches or other assistive device) for 30 minutes

Exclusion Criteria

1. Total knee replacement patients (patients who have already undergone surgery or patients who are planned for surgery)
2. Rheumatoid arthritis or other form of inflammatory arthritis such as crystal arthropathy or septic arthritis
3. Hip osteoarthritis
4. Participants in other experimental research studies (including but not limited to the Vitamin D study and the COOA study)
5. Poor eyesight which could restrict the ability ro understand and use the real-time visual feedback

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The first peak of the knee adduction moment. This is generally accepted to be a representation of the knee joint loading in the medial compartment of the knee and is an important measure in patients with medial knee osteoarthritis. It is calculated from the measurement of the knee joint position using motion capture equipment and the ground reaction forces using two force plates. In this study a comparison of the first peak of the knee adduction moment is made at baseline, end of training programme (week six) and three and six month follow up (3 and six months after the last training session).

Secondary Outcome Measures

Name	Time	Method
1. Pain, functional ability and knee joint stiffness is measured using the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index, https://www.rheumatology.org/I-Am-A/Rheumatologist/Research/Clinician-Researchers/Western-Ontario-McMaster-Universities-Osteoarthritis-Index-WOMAC) questionnaire at baseline, end of training programme (week six) and 3 and 6 month follow up (3 and 6 months after the last training session)<br>2. Self-reported pain is measured using a NRS (numeric rating scale) at baseline, end of training programme (week six) and 3 and 6 month follow up (3 and 6 months after the last training session)