Effects of Chocolate on Coronary Vasomotion in Patients After Heart Transplantation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
研究概览
简要总结
The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
详细描述
Dark chocolate contains a high amount of flavonoids. Flavonoids hold the possibilities to improve oxidative stress and hence the possibility to improve endothelium-dependent coronary vasomotion, which is a powerful surrogate for clinical prognosis. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. High oxidative stress and reduced antioxidant defenses play a crucial role in the pathogenesis of atherosclerosis, in particular in transplanted hearts. The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients after heart transplantation not requiring immediate coronary intervention
- •Age 20 - 80
- •Written obtained informed consent
排除标准
- •Heart failure (acute or chronic >NYHA II)
- •Ventricular tachy-arrythmias or AV-Block >I°
- •Renal insufficiency (>200 μmol/l) or liver disease (ALT or AST >150 IU)
- •Symptomatic hypotension, hypertension >160/100mmHg
- •Known allergy to compounds dark chocolate
- •Acute infectious disease
- •Disease with systemic inflammation (e.g. rheumatoid arthritis, M. Crohn)
- •Participation in another study within the last month
- •Concomitant vitamin supplements