The impact of cognitive training on cognitive outcomes following coronary artery bypass grafting surgery in older adults.

Not Applicable

Completed

• Conditions: Cognition; Delirium; Neurological - Other neurological disorders

• Registration Number: ACTRN12618000799257
• Lead Sponsor: The University of South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-10
• Study Completion: 2022-10-21
• Last Update Posted: 18 September 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Persons must be undergoing elective CABG surgery at the Royal Adelaide Hospital aged 65 years and over. Must be proficient English speakers, have normal vision and hearing with or without the use of aids, live within metropolitan boundaries of Adelaide (Development Act 1993) and be willing to participate in a longitudinal study with follow-up sessions.

Exclusion Criteria

* Known learning disabilities or dementia diagnosis, a significant neurological/ psychiatric diagnosis (all factors will affect ability to perform assessments)
* History of cancer treatment within the past 5 years (excluding pure surgical treatment) [as cancer treatment is known to negatively affect cognition ]).
* Suffered a stroke within the past year (many stroke related cognitive impairments subside within a year)
* Currently practicing cognitive training (will interfere or muddle cognitive training effects).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognition<br>Measured by the Addenbrookes Cognitive Examination-III and a 5 assessment battery on the CANTAB system (MOT, RTI, PAL, SWM and OTS).[ Baseline (2 weeks prior to surgery), Discharge (day after discharge), 4-months post-surgery [Primary Timepoint], 6-months post-surgery, 12-months post-surgery and 3 years post-surgery<br>];Delirium<br>Measured in ICU (CAM-ICU and RASS)<br>Measured in ward (MDAS, OSLA and CAM)<br>Weekends, chart based review delirium method conducted on Monday (data for Saturday and Sundays)[ In hospital, in ICU (daily until moved to ward) and daily within ward until discharge. Additional day after discharge measure during discharge assessment [Primary Timepoint]. ]

Secondary Outcome Measures

Name	Time	Method
Depression measured by Geriatric Depression Scale: short form[ Baseline (2 weeks prior to surgery), Discharge (day after discharge), 4-months post-surgery, 6-months post-surgery, 12-months post-surgery and 3 years post-surgery];Dementia Risk measured with the Australian National University - Alzheimer’s Disease Risk Index (ANU-ADRI)[ Baseline (2 weeks prior to surgery), 6-months post-surgery, 12-months post-surgery and 3 years post-surgery];Disability measured with the World Health Organisation Disability Assessment Schedule 2.0 -WHODAS 2.0 12-item[ Baseline (2 weeks prior to surgery), 6-months post-surgery, 12-months post-surgery and 3 years post-surgery];Quality of Life measured with the World Health Organisation Quality of Life Brief Questionnaire- WHOQOL-BREF[ Baseline (2 weeks prior to surgery), 6-months post-surgery, 12-months post-surgery and 3 years post-surgery]