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Can the antibiotic Doxycycline help control the complications (dyskinesias) of levodopa treatment in patients with Parkinson's Disease?

Phase 1
Conditions
Drug induced chorea
Registration Number
RBR-1047fwbf
Lead Sponsor
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruitment completed
Sex
Not specified
Target Recruitment
Not specified
Inclusion Criteria

Patients 18 years of age or older; diagnosed with Parkinson's disease according to the United Kingdon Parkinson's Disease Society Brain Bank clinical diagnostic criteria; presenting at the initial evaluation with at least some functional impact dyskinesias (score higer than1 on item 4. 2 of the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS); who are using levodopa at least three times a day; and who can keep doses of antiparkinsonian medications unchanged for at least four weeks prior to screening and during study participation.

Exclusion Criteria

Diagnosis of atypical or secondary parkinsonism; treatment of any experimental drug or other intervention within 90 days prior to screening or baseline assessment; presence of moderate or severe psychotic symptoms (score greater than 2 on item 1. 2 of the Movement Disorders Society's Unified Scale for Assessment of Parkinson`s disease; diagnosis of dementia according to the Movement Disorders Society diagnostic criteria; suffering from serious systemic conditions (infections, malignancies, chronic kidney or liver disease); pregnancy or lactation; history of hypersensitivity or allergic reaction to tetracyclines; absence of clinical dyskinetic movements at baseline assessment.

Study & Design

Study Type
Intervention
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Secondary Outcome Measures
NameTimeMethod
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