Mycological Comparative Study on Maxillary Dentures of Two Different Materials

Not Applicable

• Conditions: Effect of Tio2 Nanoparticles on Candida Aggregation
• Interventions: Other: titanium dioxide denture

• Registration Number: NCT03700489
• Lead Sponsor: Ali ibrahim mahmoud shamardal

Brief Summary

Cross over design the investigator divide participants to two groups group (A) will receive rapid heat cured denture base material and group (b) will receive the acrylic denture modified by titanium dioxide nanoparticles and after washout period alternatively group (a) will receive the acrylic denture modified by titanium dioxide nanoparticles AND group (b) will receive rapid heat cured denture base material the investigator will take swaps from dentures to count the candida species

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-09-26
• Status Verified: 2018-10
• Study First Submitted QC: 2018-10-07
• Last Update Submitted: 2018-10-07
• Study First Posted: 2018-10-09
• Last Update Posted: 2018-10-09
• Study Start: 2018-10-20
• Primary Completion: 2019-05-01
• Study Completion: 2019-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Completely edentulous maxillary arch and partially dentate mandibular arch with adequate interarch space.
• The edentulous ridges should be covered by firm healthy mucosa.
• Angle class I maxillomandibular relation.
• Healthy and cooperative patient

Exclusion Criteria

• Patients with bad habits as severe clenching or bruxism, drug or alcohol addiction, moderate or heavy smoking (greater than 10 cigarettes per day).
• Previous history of radiotherapy or chemotherapy.
• Any skeletal problem dictates surgical intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
patients take rapid heat denture	titanium dioxide denture	patients will receive rapid heat denture for 1 month in the initial phase of the trial then in the later phase patients will receive titanium dioxide denture (made from conventional acrylic resin modified by titanium dioxide nanoparticles )
patients take titanium dioxide denture	titanium dioxide denture	patients will receive titanium dioxide denture (made from conventional acrylic resin modified by titanium dioxide nanoparticles ) for 1 month in the initial phase of the trial then in the later phase after one month they will receive( rapid heat cured acrylic resin)denture

Primary Outcome Measures

Name	Time	Method
Mycological investigation	6 months	Count of candida on the fitting surface of denture by (CFU) unit