ACTRN12615000766516招募中4 期
A pilot study comparing inhaled hypertonic to normal saline on the respiratory function of children with neurological impairment and acute lower respiratory tract infection
Paediatric Intensive Care Unit, Royal Children's Hospital Melbourne0 个研究点目标入组 10 人开始时间: 2015年7月23日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 2 Years 至 18 Years（—）
- 性别
- All
入选标准
- •Participants must meet the following criteria:
- •Be aged between 2 and 18 years of age.
- •Have a diagnosis of CP GMFCS level IV or V or other neurological impairment with equivalent functional impairment including children with; developmental delay, chromosomal abnormalities, neurodegenerative and metabolic conditions.
- •Have a clinical diagnosis of LRTI caused by either aspiration pneumonia, bacterial pneumonia, or viral infection.
- •Must require at least one of oxygen therapy, high flow nasal prongs (HFNP), biphasic positive airway pressure (BIPAP), continuous positive airway pressure (CPAP), or mechanical ventilation.
排除标准
- •Acute wheeze associated with severe bronchospasm.
- •Known intolerance of hypertonic saline within the last 12 months.
- •Neuromuscular conditions.
- •Active pulmonary haemorrhage.
- •Low platelets (less than 20).
- •Undrained pneumothorax.
- •High cardiovascular instability.
- •Requiring extracorporeal membrane oxygenation or high frequency oscillation ventilation.
研究者
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