To see effects of oral melatonin and oral zolpidem on blood pressure, heart rate in patients undergoing surgery under general anaesthesia.
Phase 4
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/02/049527
- Lead Sponsor
- Department of Anaesthesia and Intensive Care
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients scheduled to undergo elective surgery.
2. American Society of Anaesthesiologist(ASA) physical status I/II
3. Age 20-60 years of either gender
Exclusion Criteria
1. Patients with anticipated difficult airway and requiring >2 attempts and >15 seconds for intubation
2. Patients refusing to give Informed Consent
3.Pregnancy, history of mental illness, Bleeding diathesis, Severe cardiovascular, respiratory, hepatic or renal diseases
4. Receiving treatment with any of study drugs
5. Known allergy to study drugs
6. Morbid obesity (BMI >35 kg/m2)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare efficacy of oral melatonin versus oral zolpidem for attenuation of hemodynamic response (systolic blood pressure, diastolic blood pressure, mean blood pressure, heart rate) to intubation in adult patients undergoing elective surgeries.Timepoint: Baseline, 1 minute, 2 minutes, 3 minutes, 5 minutes, 10 minutes and 30 minutes
- Secondary Outcome Measures
Name Time Method Total induction agent used intraoperative, Total opioid used intraoperative and adverse effects of drugTimepoint: Intraoperative, Intraoperative, Intraoperative and postoperative