Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates

Withdrawn

• Conditions: Coronary Artery Disease

• Registration Number: NCT00727051
• Lead Sponsor: University of California, San Francisco

Brief Summary

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2007-06
• Study First Submitted: 2008-07-29
• Study First Submitted QC: 2008-07-31
• Study First Posted: 2008-08-01
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-18
• Last Update Posted: 2019-07-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Liver transplant candidates referred for invasive coronary angiography which include:

   • Patients with suspicious symptoms for CAD or;
   • Asymptomatic patients;
   • Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo.

2. Lung transplant candidates referred for invasive coronary angiography which include:

   • Patients with suspicious symptoms for CAD or;
   • Asymptomatic patients;
   • Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF < 60% on echo in patients with low SVR (typical for ESLD).

3. Any ethnic background is acceptable.

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Exclusion Criteria

1. Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded.
2. Children and pregnant women will be excluded because of risks associated with radiation exposure.
3. Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination.
4. Patients unable to give informed consent will be excluded as well.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
patients suspected of having coronary artery disease (CAD)	1-30 days before invasive coronary angiography is performed

Trial Locations

Locations (1)

UCSF Medical Center; 🇺🇸 San Francisco, California, United States