RL Versus Glucose Saline in Cancer Patient Undergoing Major Surgeries and Its Impact on Electrolytes, GLC & pH
- Conditions
- Fluid and Electrolyte Imbalance
- Registration Number
- NCT05810662
- Lead Sponsor
- National Cancer Institute, Egypt
- Brief Summary
To compare two electrolytes maintenance in perioperative period in children undergoing major surgeries on perioperative change in pH,lactate,sodium and glucose level
- Detailed Description
Patients were randomized into 2 groups ringer lactate versus 5%dextrose in 0.9% saline,using a computer generated random list in blocks of 4 after recruitment the enrolling investigators opened sealed opaque envelopes that concealed group allocation participants ,trial investigators,attending anesthetist providing general anesthesia for the cases and the outcomes were blinded to group allocation
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 60
- 1to 10 years Children undergoing major surgeries ie considered major if any invasive procedure in which extensive resection will be preformed e.g body cavity is opened,organs are removed and normal anatomy is altered abd duration not less than 2 hours or more than 5 hours.
-
patient guardian refusal
_ Children with documented endocrine distrubances(DM,inborn error of metabolism,hyperthyroidism)
-
age less than one year
-
preexisting renal disease,hepatic disease and patien suffering from heart failure.
-
preexisting electrolyte imbalance (normal sodium level 135-145)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method PH and lactate level In the introperative period Three ABG will be collected from the patient. The first at start before any intervention,the second after start of replacement and the third at the end of the operation.
- Secondary Outcome Measures
Name Time Method Sodium and glucose level The intraoperative period Three ABGs will be collected.The first at the start of the operation before any surgical intervention,the second after the start of fluid replacement and the last sample at the end of the operation.
Trial Locations
- Locations (1)
National Cancer institute
🇪🇬Cairo, Egypt
National Cancer institute🇪🇬Cairo, Egypt