Treatment strategies for Rheumatoid Arthritis (BeSt - BehandelStrategieën in Reumatoïde Artritis)

eiden University Medical Centre (LUMC) (Netherlands)0 个研究点目标入组 508 人开始时间: 2005年12月20日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Patients (18 years or older) with rheumatoid arthritis (American College of Rheumatology [ACR] 1987 criteria)
•2. Diagnosis since less than two years
•3. Previously untreated with DMARDs
•4. With active disease (at least 6/66 swollen and at least 6/68 painful joints, and either Erythrocyte Sedimentation Rate [ESR] 28 mm or more or Visual Analogue Scale [VAS] general well being (by patient) of 20 mm or more)

•1. Previous therapy with DMARDs except for hydroxychloroquine
•2. Pregnancy or wish to become pregnant during the study, or childbearing potential without adequate contraception
•3. Concomitant treatment with another experimental drug
•4. History or presence of malignancy within the last five years
•5. Bone marrow hypoplasia
•6. Elevated hepatic enzyme levels (Aspartate Aminotransferase [ASAT], Alanine Aminotransferase [ALAT] greater than three times normal value)
•7. Serum creatinine level greater than 150 umol/l or estimated creatinine clearance of less than 75 ml/min
•8. Diabetes mellitus
•9. Alcohol or drug abuse

发起方

eiden University Medical Centre (LUMC) (Netherlands)