Treatment strategies for Rheumatoid Arthritis (BeSt - BehandelStrategieën in Reumatoïde Artritis)

eiden University Medical Centre (LUMC) (Netherlands)0 sites508 target enrollmentDecember 20, 2005

Overview

No summary available.

Registry

who.int

Start Date

December 20, 2005

End Date

TBD

Last Updated

11 years ago

Study Type

Interventional

Sponsor

eiden University Medical Centre (LUMC) (Netherlands)

•1\. Patients (18 years or older) with rheumatoid arthritis (American College of Rheumatology \[ACR] 1987 criteria)
•2\. Diagnosis since less than two years
•3\. Previously untreated with DMARDs
•4\. With active disease (at least 6/66 swollen and at least 6/68 painful joints, and either Erythrocyte Sedimentation Rate \[ESR] 28 mm or more or Visual Analogue Scale \[VAS] general well being (by patient) of 20 mm or more)

•1\. Previous therapy with DMARDs except for hydroxychloroquine
•2\. Pregnancy or wish to become pregnant during the study, or childbearing potential without adequate contraception
•3\. Concomitant treatment with another experimental drug
•4\. History or presence of malignancy within the last five years
•5\. Bone marrow hypoplasia
•6\. Elevated hepatic enzyme levels (Aspartate Aminotransferase \[ASAT], Alanine Aminotransferase \[ALAT] greater than three times normal value)
•7\. Serum creatinine level greater than 150 umol/l or estimated creatinine clearance of less than 75 ml/min
•8\. Diabetes mellitus
•9\. Alcohol or drug abuse