The Relation Between MiR-125b-5p and Staging of Endometriosis

Not Applicable

Completed

• Conditions: Endometriosis
• Interventions: Diagnostic Test: Blood sampling; Procedure: laparoscopic examination

• Registration Number: NCT05556213
• Lead Sponsor: Tanta University

Brief Summary

78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2020-05-12
• Primary Completion: 2022-01-11
• Study Completion: 2022-07-15
• Status Verified: 2022-09
• Study First Submitted: 2022-09-24
• Study First Submitted QC: 2022-09-24
• Last Update Submitted: 2022-09-24
• Study First Posted: 2022-09-27
• Last Update Posted: 2022-09-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 89

Inclusion Criteria

• Patients who presented clinical pictures suggestive of EM disease

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Exclusion Criteria

• Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination,
• patients who were suspicious of having malignancy elsewhere in the body region,
• pregnant women,
• patients who had diabetes mellitus,
• body mass index (BMI) of >30 kg/m2, coagulopathies, and autoimmune disorders.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Blood sampling	-
Patients	laparoscopic examination	-

Primary Outcome Measures

Name	Time	Method
Validity of Plasma expression level	two weeks	the diagnostic validity of estimation of plasma expression levels of MiR-125b-5p and 203a for diagnosis and staging of endometriosis.

Trial Locations

Locations (1)

Tanta university; 🇪🇬 Tanta, El-Gharbyia, Egypt