Estimation of Plasma Levels of MicroRNA 125b-5p and Transvaginal Ultrasonography May Spare Laparoscopy for Staging of Endometriosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 89
- 试验地点
- 2
- 主要终点
- Validity of Plasma expression level
研究概览
简要总结
78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 22 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients who presented clinical pictures suggestive of EM disease
排除标准
- •Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination,
- •patients who were suspicious of having malignancy elsewhere in the body region,
- •pregnant women,
- •patients who had diabetes mellitus,
- •body mass index (BMI) of >30 kg/m2, coagulopathies, and autoimmune disorders.
结局指标
主要结局
Validity of Plasma expression level
时间窗: two weeks
the diagnostic validity of estimation of plasma expression levels of MiR-125b-5p and 203a for diagnosis and staging of endometriosis.
次要结局
未报告次要终点
研究者
Ahmed Hagars
Assistant professor of gynecology
Tanta University