Dynamic ASPECTS of Internal PRE-ACTIVATION of Effects Sensors of Voluntary ACTION in PARKINSON's Disease

Completed

• Conditions: Parkinson's Disease
• Interventions: Behavioral: Behavioral observation

• Registration Number: NCT02894320
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

The ability to predict sensory effects of people's own motor actions is a key component of Human action realization. Recent studies revealed this anticipation process to be involved in early and late stages of voluntary actions. Nevertheless, the question whether the action-effect anticipation is impacted or not by "motor pathologies", such as the Parkinson's disease, remains unclear. The current study is aimed to clarify this issue by using a subliminal priming paradigm in patients with Parkinson's disease and in matched control participants. Indeed, subliminal primes corresponding to visual action-effects are displayed at different time points before the actions' execution. Results should allow to determine whether or not the action-effect prediction is impaired at different stages of voluntary action in patients with Parkinson's disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2016-06
• Study First Submitted: 2016-09-05
• Study First Submitted QC: 2016-09-05
• Study First Posted: 2016-09-09
• Study Completion: 2017-09
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-30
• Last Update Posted: 2018-08-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Adults age 18 years and older
• Parkinson's disease

Exclusion Criteria

• Other pathology or neurological or psychiatric history
• Known pregnancy or breastfeeding
• Absence of affiliation to social security or universal health coverage (CMU)
• Person under legal protection
• Patient's opposition to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parkinson's disease	Behavioral observation	-
Healthy subjects	Behavioral observation	gender and age matched with Parkinson's disease patients, whose data will be extracted from an existing database

Primary Outcome Measures

Name	Time	Method
Reaction time	baseline	time measured in seconds
error rate	baseline

Trial Locations

Locations (1)

Fondation Ophtalmologique Adolphe de Rothschild; 🇫🇷 Paris, France