Rotational Thromboelastometry Guided Blood Component versus conventional blood product transfusion to prevent bleeding in children with liver involvement undergoing invasive tests
- Conditions
- Health Condition 1: K740- Hepatic fibrosis
- Registration Number
- CTRI/2020/11/029132
- Lead Sponsor
- ILBS hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Children less than 18 years of age with histologic or image proven liver cirrhosis of any etiology with INR � 1.5- � 2.5 and/or PLT count 20,000/mm3- 50,000/mm3 and who are listed for the following invasive procedures :
Low risk of bleeding
Central venous cannulation
Haemodialysis catheter
Ascitic or Pleural tapping
EVL
EST
High risk of bleeding
TIPPS
ERCP with sphicterotomy
PCD Insertion
Biopsies other than liver biopsy
AND
Children less than 18 years of age with histologic or image proven liver cirrhosis of any etiology with INR � 1.5- � 2.0 and/or PLT count 40,000/mm3- 60,000/mm3 and who are listed for Liver biopsy
Anti platelet or anti coagulant therapy in the previous 7 days
Patients with clinical evidence of DIC and/or active bleeding
Hemodialysis in the past 7 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison in the amount of blood products transfused between the groups <br/ ><br>To compare the amount of total component transfused (ml/kg) in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosis <br/ ><br>To compare the amount of total component transfused (ml/kg) in Rotational Thromboelastometry guided therapy versus Conventional therapy for invasive procedures in children with cirrhosisTimepoint: 24 hours
- Secondary Outcome Measures
Name Time Method