Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cervical Spinal Cord Injury
- Sponsor
- Columbia University
- Enrollment
- 36
- Locations
- 2
- Primary Endpoint
- Efficacy of epidural SCS
- Status
- Recruiting
- Last Updated
- 5 months ago
Overview
Brief Summary
The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).
Detailed Description
For people with cervical spinal cord injury (SCI), regaining hand and arm function is their highest priority. Epidural stimulation enables recovery of walking and autonomic function in people with chronic SCI, but how the spinal cord should be stimulated to restore arm and hand function is not known. This project seeks to advance our understanding of how best to apply epidural electrical stimulation (EES) after cervical SCI using complementary experiments in humans and rats. This improved understanding will be used to conduct a preclinical study of the efficacy of different sites of cervical spinal cord stimulation.
Investigators
Jason Carmel
Associate Professor
Columbia University
Eligibility Criteria
Inclusion Criteria
- •Clinical indication for cervical spine surgery.
- •Exclusion criteria:
- •Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Efficacy of epidural SCS
Time Frame: 0-100 milliseconds after each stimulation event during the experiment
Efficacy of stimulation is calculated as 1/threshold for provoking an motor evoked potentials. The threshold will be calculated from the recruitment curves.
Selectivity of epidural SCS
Time Frame: 0-100 milliseconds after each stimulation event during the experiment
Selectivity is calculated from the recruitment curves of the target muscle compared to non-targeted muscles.