A comparative evaluation to study the effects of intravenous dexmedetomidine versus intravenous clonidine on haemodynamic response to endotracheal intubation under general anaesthesia- a prospective, comparative study.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- To compare the effect of single pre operative dose of Dexmedetomidine and Clonidine on haemodynamic response to endotracheal intubation under general anaesthesia.
Study Overview
Brief Summary
Randomized and observational study to compare the effect of single pre-operative dose of dexmedetomidine and clonidine on haemodynamic response to endotracheal intubation under general anaesthesia. This study shall further help us to conclude a better drug for controlled attenuation of haemodynamics without any major side effects.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Randomization method
- Coin toss, Lottery, toss of dice, shuffling cards etc
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- Patients willing to sign informed consent.
- Male or female patients between ages of 18 to 60 years.
- Patients belonging to American Society of Anaesthesiologists (ASA) physical status I and II.
- Patients posted for elective surgeries requiring endotracheal intubation under general anaesthesia.
- Patient having mouth opening more than 3cm Patient with Malampatti grade 1 and 2.
Exclusion Criteria
- Patients unwilling to participate in the study.
- Patients belonging to ASA status 3 and 4 Patients having contraindication to endotracheal intubation/general anaesthesia.
- Patient having mouth opening less than 3cm.
- Patient with Mallampati grade 3 and 4.
- Body mass index more than 30 kg.m2.
- patients taking anxiolytics, sedatives, antipsychotic, or antiepileptic drugs.
- Patients with cardiovascular diseases, arrhythmias, heart blocks, or taking beta blockers.
- Patients with cerebrovascular, hepatic and renal diseases.
- Psychiatric patients.
- Patients with history of allergy to an alpha 2 adrenergic agonist and synthetic opioids.
- Pregnancy and lactating women.
Outcomes
Primary Outcomes
To compare the effect of single pre operative dose of Dexmedetomidine and Clonidine on haemodynamic response to endotracheal intubation under general anaesthesia.
Time Frame: To compare the effect of single pre operative dose of Dexmedetomidine and Clonidine on haemodynamic response to endotracheal intubation under general anaesthesia (Baseline parameters before administration of the study drug, after 5 minutes during the administration of the study drug, just after administration of the study drug, after induction of anaesthesia, after intubation, and at 1,3,5,10,15 minutes post intubation.
Secondary Outcomes
- Patient haemodynamic parameters during extubation.(Post operative Sedation effect)
Investigators
Sendhooran S
Smt.Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Study Sites (1)
Identifiers
- CTRI ID
- CTRI/2026/03/105824
Dates
- Last updated
- (6 months ago)