NCT02555267已完成不适用
Multi-center, Prospective Cohort Study to Investigate the Impact of Comprehensive Geriatric Assessments on Survival and Toxicities in Elderly Diffuse Large B-cell Lymphoma Patients Treated With R-CHOP
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Event-free survival
研究概览
简要总结
This study investigate the impact of comprehensive geriatric assessments using activity of daily living (ADL), instrumental activity of daily living (IADL), and Charlson's comorbidity index (CCI) on survival and toxicities in Korean patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with newly diagnosed CD20+ DLBCL
- •65 years old or over
- •Scheduled to receive R-CHOP chemotherapy
- •Informed consent
排除标准
- •Other histology than CD20+ DLBCL
- •Primary central nervous system DLBCL
- •Patients with a diagnosis of cancer (other than basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, well differentiated thyroid cancer [papillary or follicular thyroid cancer]) within 3 years before the study entry or with any treatment for cancer within 3 years before entry
- •Consent withdrawal
结局指标
主要结局
Event-free survival
时间窗: 2 years
Event-free survival was defined as death, relapse from complete remission, progression during or after treatment, and discontinuation or changes of therapy during treatments
次要结局
- Overall survival(5 years)
- Progression-free survival(5 years)
- Cumulative incidence of grade 3/4 adverse events and premature treatment discontinuation(1 year)
研究者
Ho-Young Yhim
Assistant professor
Chonbuk National University Hospital
研究点 (1)
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