Geriatric Assessments in Elderly Diffuse Large B-cell Lymphoma

Completed

• Conditions: Lymphoma, Large B-cell, Diffuse

• Registration Number: NCT02555267
• Lead Sponsor: Chonbuk National University Hospital

Brief Summary

This study investigate the impact of comprehensive geriatric assessments using activity of daily living (ADL), instrumental activity of daily living (IADL), and Charlson's comorbidity index (CCI) on survival and toxicities in Korean patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-09
• Study First Submitted: 2015-09-17
• Study First Submitted QC: 2015-09-18
• Study First Posted: 2015-09-21
• Primary Completion: 2017-07
• Study Completion: 2020-12
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-02
• Last Update Posted: 2023-02-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 148

Inclusion Criteria

• Patients with newly diagnosed CD20+ DLBCL
• 65 years old or over
• Scheduled to receive R-CHOP chemotherapy
• Informed consent

Exclusion Criteria

• Other histology than CD20+ DLBCL
• Primary central nervous system DLBCL
• Patients with a diagnosis of cancer (other than basal or squamous cell carcinoma of the skin, cervical carcinoma in situ, well differentiated thyroid cancer [papillary or follicular thyroid cancer]) within 3 years before the study entry or with any treatment for cancer within 3 years before entry
• Consent withdrawal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Event-free survival	2 years	Event-free survival was defined as death, relapse from complete remission, progression during or after treatment, and discontinuation or changes of therapy during treatments

Secondary Outcome Measures

Name	Time	Method
Overall survival	5 years
Progression-free survival	5 years
Cumulative incidence of grade 3/4 adverse events and premature treatment discontinuation	1 year

Trial Locations

Locations (1)

Chonbuk National University Hospital; 🇰🇷 Jeonju, Korea, Republic of