Brain Connectivity and Neuroprogression. Multimodal MRI approach in victims of sexual abuse (adolescents and adults) with Post Traumatic Stress Disorder

niversidade Federal de São Paulo0 sitesDecember 8, 2021

ConditionsPost-traumatic stress disorder

Overview

Phase: 未知
Intervention: Not specified
Conditions: Post-traumatic stress disorder
Sponsor: niversidade Federal de São Paulo
Status: Active, not recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

To evaluate the structural, functional and metabolic changes in the brain in PTSD ( post traumatic stress disorder ), in a population of adolescents victims of sexual violence, using different modalities of Magnetic Resonance imaging (Structural, Functional, Spectroscopy and DTI-diffusion tensor imaging). Evaluate the effect of therapeutic interventions - interpersonal therapy s and sandpaly and on brain structure, functioning and metabolism.

Registry

who.int

Start Date

December 8, 2021

End Date

September 30, 2020

Last Updated

2 years ago

Study Type

Intervention

Sex

Female

Investigators

Sponsor

niversidade Federal de São Paulo

Eligibility Criteria

Inclusion Criteria

•Case: have been victims of sexual violence; age between 14 and 17 years; to have Post traumatic stress disorder (PTSD) diagnosis after the application of the Clinician administered PTSD scale for children and adolescents (CAPS CA) performed in the screening; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficit. Controls: did not present psychiatric diagnoses through the scale Schedule for Affective Disorders and Schizophrenia for School\-Aged Children (K\-SADS) , did not have a traumatic event of sexual violence through the CAPS\-CA scale; do not present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; do not present decompensated clinical diseases that require intensive treatment; do not present significant intellectual deficits; absence of use of psychoactive substances in the last 6 months; not being pregnant; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficits , intelligence coeficient( IQ)below 70\.

Exclusion Criteria

•Case: present psychiatric diagnoses prior to the traumatic event of sexual violence; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; Pregnancy detected through blood test.Controls: present psychiatric diagnoses; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; pregnancy detected through blood test; have been sexually abused.