Does Gabapentin reduce the incidence of chronic pain post thoracotomy?

Phase 4

• Conditions: Prevention of a chronic pain syndrome developing post thoracotomy.; Anaesthesiology - Anaesthetics; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)

• Registration Number: ACTRN12608000471381
• Lead Sponsor: Dr John Monagle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-09-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

Patients undergoing open thoracic surgery who are 18 years old or older and have an anticipated post operative stay of greater than twenty four hours.

Exclusion Criteria

Patients who have a known hyper sensitvity to Gabapentin. Women who are pregnant or breast feeding. Patients who are currently using Gabapentin. Patients who have chronic renal insufficiency (pre-operative creatinine level> 200 umol/L or are receiving dialysis. Patients with a history of chronic pain syndrome. patients currently using Cimetidine or regular antacids or have a history of epilepsy or seizures. Patients with a history of alcoholism or recreational drug use.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the impact of Gabapentin on post thoracotomy pain at three months we will invite the participants to attend an out patient appointment at the Pain Management Clinic. Primary outcomes will be measured by the participant's activities, the presence or absence of persistant pain, length of rehabilitation (either in an approved centre or with relatives), if they have achieved unrestricted daily living activities and the date that they have returned to work. A 15 item short form McGill Questionnaire will be completed and measurements of punctuate hyperalgesia around the thoracotomy incision with a von Frey device will also take place at this final assessment.[Baseline, three weeks and three months post operatively.]