31P Magnetic Resonance Spectroscopy Fructose Study
- Conditions
- Healthy
- Interventions
- Dietary Supplement: Fructose
- Registration Number
- NCT02217605
- Lead Sponsor
- Stephen Bawden
- Brief Summary
The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
- Detailed Description
This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
- Male
- Age 18 - 30
- BMI 20 - 27 kg/m^2
- Healthy
- Smokers
- Liver disease or Metabolic Disorders
- Metal implants (not suitable for MRI)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Fructose Fructose Oral Fructose Challenge (75 g fructose in 500 ml water) followed by 75 minutes 31P MRS
- Primary Outcome Measures
Name Time Method Hepatic ATP reserves following an oral fructose challenge 2 hours post prandial Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy
- Secondary Outcome Measures
Name Time Method Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen 2 hours post prandial Measure baseline liver lipid and glycogen using magnetic resonance spectroscopy and correlate BMI, lipid and glycogen levels with rate of ATP depletion and recovery following an oral fructose challenge
Trial Locations
- Locations (1)
University of Nottingham
🇬🇧Nottingham, Nottinghamshire, United Kingdom