Ayurvedic management of polycystic ovarian syndrome in adolescents and young adults
- Conditions
- Health Condition 1: N830- Follicular cyst of ovary
- Registration Number
- CTRI/2023/03/050440
- Lead Sponsor
- Archana S
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Adolescent girls of age group 13-19 years(age based on evidence from researches, those who were within gynecological age of 8 years or less than 8 years post menarche were also included.)
2.Young Adults in the age group 19-25years.
3. Overweight and Obese girls with BMI >23(WHO Asian BMI classification)
4. Adolescent after 2 years of menarche.
5. Adolescent who are at risk of PCOS,newly Diagnosed and already diagnosed (with in 3 years) cases of PCOS will be included in the study.
6.Any one or two following feature of Artavadusti
A. Artavakshaya- Oligomenorrhoea or Amenorrhoea( > 1yr postmenarche, 90 days for any cycle)
B. Atipravruti & Vikruti -Menstrual irregularities ( <12 or >45 days in >1 to <3yrs
and <21 to > 35 days in >3 yrs postmenarche.)
7. Hyperandrogenism(clinical/Biochemical)
a. Clinical- Hirsutism,Acne,Male pattern
alopecia(Any one)
b. Biochemical- Increase S. Total
Testosterone
HIR was defined by a modified Ferriman -Gallway(mFG) SCORE OF >6.
Hyperandrogenemia was defined by an androgen value exceeding the 95th percentile of 98 race-matched eumenorrheic control women from the same population,as previous reported testosteron (T) >88ng/dL.
On Physical examination ,in addition to measuring height, weight and mFG, the waist circumference measured at the narrowest portion of trh torso, approxmately midway between the lower costal margin and iliac crest.
the Hip circumference was measured over thw widest portion of the gluteal and greater trochanteric region.
1. Pelvic/systematic disease causing the oligomenorrhea and Anovulation.
2. Organic lesion of reproductive tract like T.B, Carcinoma and congenital deformities.
Patient suffering from the ant of the following clinical condition will be excluded
a. Congenital Adrenal Hyperplasia
b. Androgen secreting Neoplasm
c. Cardiac Disease
d. Cushing Syndrome
4. Patient suffering from uncontrolled Diabetic (FBS >150mg)or Hypertension ( >130/90 mm/Hg)
5.Unwilling patients
6.Pregnancy
7.Below age of 13 yrs and above the age of 25yrs.
8.Married Patient.
9.Current and previous(with in last 3 months) use of OC pills,Glucocorticoids,Anti-androgens,Anti-obesity and Antidiabetic or other hormonal medication.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Change in features of oligomenorrhoea/Anovulation <br/ ><br> <br/ ><br>2. Reduction of weight by 5%Timepoint: Base line and at 3 months
- Secondary Outcome Measures
Name Time Method 1. Improvement in Metabolic and hormonal parameters. <br/ ><br>2. Reduction in the Waist/Hip Ratio, <br/ ><br>3. Change in the clinical findings of Hyperandrogenism like Acne (Global acne grading system),Hirsutism (Modified Ferriman gallwey score) <br/ ><br>4. Improvement in Quality of life(SF-36 Questionnaire)Timepoint: Base line and at 3 months