Neural Response to Food Stimuli: fMRI Changes Following Cognitive Behavioral Therapy for Binge Eating Disorder
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Binge Eating Disorder
- Sponsor
- University of Pennsylvania
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Blood Oxygen Level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Response to Food-specific Stop-signal Task
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this research is to conduct a randomized controlled trial (RCT) assessing the impact of CBT on neural responses to binge eating stimuli.
Detailed Description
Females with a BMI\>/=25 kg/m2 and BED will be randomized to either a 16-week, one-on-one CBT intervention (n=20) or a waitlist control (WL; n=20). Both groups will have blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) scans at baseline and after the 16-week intervention. During the scans, participants will complete the following tasks: 1) food-specific stop signal task (SST), and 2) script-driven imagery of binge foods.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Women who meet the DSM-5 criteria for BED as diagnosed by the Eating Disorder Examination Interview
- •Ages 18 to 45 years of age
- •BMI \>/=25 kg/m2
- •Premenopausal
- •Able to provide informed consent
- •Right-handed
- •Eligible female patients will be:
- •Non-pregnant, evidenced by a negative urine dipstick pregnancy test
- •Non-lactating
- •Surgically sterile or postmenopausal, or they will agree to continue to use an accepted method of birth control during the study
Exclusion Criteria
- •Weight \> 158.8 kg (350 lbs, due to scanner weight restrictions)
- •Supine abdominal width (with arms folded above) \> 70 cm or sagittal diameter \> 50 cm (due to scanner dimension restrictions)
- •Pregnant or nursing (or plans to become pregnant in the next 5 months)
- •Evidence of psychiatric disorder that significantly interferes with daily living
- •Active suicidal ideation
- •Type 1 diabetes or type 2 diabetes or A1C \> 6.5%
- •Use of weight loss medications or other agents known to affect body weight (e.g., oral glucocorticoids, second-generation antipsychotic medications) in the past 3 months
- •Psychiatric hospitalization within the past 6 months
- •Self-reported alcohol or substance abuse within the past 12 months, including at-risk drinking (current consumption of ≥ 14 alcoholic drinks per week)
- •Self-reported use of illicit drugs within the past 30 days
Outcomes
Primary Outcomes
Blood Oxygen Level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Response to Food-specific Stop-signal Task
Time Frame: Change from baseline to 16 weeks
BOLD fMRI (neural) response to high-calorie food cues during the food-specific stop-signal task in reward regions of interest. Reward-regions included BOLD response of the combination of prefrontal cortex, orbitofrontal cortex, insula, ventral tegmental area, and ventral striatum
Blood Oxygen Level-dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Response to Binge-eating Script-driven Imagery
Time Frame: Change from baseline to 16 weeks
BOLD fMRI response to descriptions of binge eating episodes during script-driven imagery (contrast in reward-regions of interest between food vs neutral stimuli). Reward-regions included combination of BOLD response in the prefrontal cortex, orbitofrontal cortex, insula, ventral tegmental area, and ventral striatum.
Secondary Outcomes
- Binge Eating Episodes(Change from baseline to 16 weeks)
- Reward-based Eating Drive(Change from baseline to 16 weeks)
- Dietary Disinhibition(Change from baseline to 16 weeks)