Diet and Vascular Health

Not Applicable

Completed

• Conditions: Topic: Primary Care Research Network for England, Cardiovascular; Subtopic: Not Assigned, Cardiovascular (all Subtopics); Disease: Cardiovascular, All Diseases; Circulatory System; Cardiovascular disease

• Registration Number: ISRCTN20997112
• Lead Sponsor: Institute of Food Research (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04-29
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 54

Inclusion Criteria

1. Men and women aged greater than or equal to 50 years
2. Recruited onto the study using the JBS cardiac risk assessor calculator. Scores of 1020% will be acceptable for participation in the study.
3. Total cholesterol greater than or equal to 5.0 mmol/L
4. Blood pressure measurements: systolic greater than or equal to 120 mmHg, diastolic greater than or equal to 80 mmHg
5. Body mass index (BMI) greater than 20 kg/m^2

Exclusion Criteria

1. Diagnosed diabetics
2. Fasting glucose greater than 6 mmol/L
3. Blood pressure less than 90/50 mmHg or 95/95 mmHg if symptomatic; greater than 160/100 mmHg
4. Chronic kidney disease
5. Those on hypolipidemic therapy
6. Those who have suffered a cardiovascular event like stroke, myocardial infarction, trans ischemic attacks etc within 2 years
8. Peripheral vascular disease including claudication
9. Consumption of fish oil supplements (unless volunteer is willing to discontinue their use at least 4 weeks prior to intervention starting)
10. Parallel participation in another research project which involves dietary intervention and/or sampling of biological fluids/materials
11. Any person related or living with any member of the study team
12. Participation in another research project which involves blood sampling within the last four months; blood from both studies should not exceed 470 mL
13. BMI less than 20 kg/m^2 or BMI greater than 40 kg/m^2
14. Fasting total cholesterol greater than 8.0 mmol/L
15. Gastrointestinal disease (excluding hiatus hernia) unless symptomatic or study intervention/procedure is contraindicated
16. Going on holiday for more than 7 days in any single period or within 2 weeks of their clinical appointment at the CRTU
17. Currently suffering from or have suffered from any neck and throat injuries and surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified