Body Composition in Older Adults

Not yet recruiting

• Conditions: Sarcopenia in Elderly; Cachexia; Cancer; Sarcopenia; Body Composition Changes; Older Adults; Nutrition

• Registration Number: NCT06630754
• Lead Sponsor: Royal Marsden NHS Foundation Trust

Brief Summary

The primary aim of the study is to explore body composition in older adults (aged 70 years and over) with cancer, undergoing systemic anticancer treatment. Additional aims include to explore the extent of body composition changes and whether changes are tumour specific, the incidence for cancer-related cachexia and sarcopenia and finally, how body composition can inform nutritional management of older adults with cancer.

To do this, the investigators applied for and were awarded funding from a company called Nutricia to pay for a band 4 (0.6 WTE for 7 months) to take monthly body composition measures on the patients who are eligible, accepting of assessment by the Senior Adult Oncology Programme (SAOP) and consent to these measures. Measurements will include an analysis from the Bioelectrical Impedance Analysis (BIA) machine which will quantify fat, lean muscle, and water content; waist to hip ratio; handgrip strength; calf circumferences. Socio-demographic data will also be collected.

Descriptive data analysis will take place to explore possible trends and associations which may inform future research and drive even further personalised care for this growing and typically underrepresented in research, population.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-09-19
• Status Verified: 2024-10
• Study First Submitted QC: 2024-10-04
• Last Update Submitted: 2024-10-04
• Study First Posted: 2024-10-08
• Last Update Posted: 2024-10-08
• Study Start: 2024-11-01
• Primary Completion: 2025-06-01
• Study Completion: 2025-06-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Adults eligible and accepting of assessment in the SAOP.

  1. adults aged 70 years and over
  2. a cancer diagnosis
  3. just starting SACT
  4. able to provide at least 2 data sets during the study period (baseline + at least 1 research clinic visit)
  5. willing and able to provide written informed consent

Exclusion Criteria

• No further exclusions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Explore body composition in older adults with cancer starting SACT.	7 months	means and standard deviations (or medians and interquartile ranges if not normally distributed) of body composition measures taken from all participants at baseline/ first Research Clinic, analysed at end of study will quantify this objective.

Secondary Outcome Measures

Name	Time	Method
Explore the extent of body composition changes in older adults with cancer during SACT.	7 months	percentage change between body composition measures taken from all participants at baseline and during monthly Research Clinics, analysed at end of study will quantify this objective.

Trial Locations

Locations (1)

Royal Marsden Hospital; 🇬🇧 London, United Kingdom